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KMID : 1189420200330040044
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2020 Volume.33 No. 4 p.44 ~ p.54
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Effect of Herbal Mixture including Lycii Fructus (HML) on Stress Relief and Melatonin in Caffeine and Light induced Stress Animal Model
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Kim Ee-Hwa
Hwang Dong-Suk
Kim Hee-Taek
Kim Yong-Min
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Abstract
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Objectives : In the present study, we investigated whether or not an herb mixture including Lycii fructus(HML) has attenuation effects on light stress in rats.
Methods : Light stress was induced by exposure to 300 lx of constant lifht for 24 h and 1㎎/㎏ of caffeine was injected into the rat. Rats were orally treated with distilled water of HML for 21 days at 100㎎/㎏/d. The changes of mortality rate, clinical signs, body, blood chemistry, melatonin and IL-2 expression were analyzed after experiment.
Results : Normal weight changes were observed in all treatment groups. In addition, no changes were observed in dead
animals and general symptoms. At the time of autopsy, the appearance of all groups and gross examination of major organs were observed, and no gross findings were observed. Blood biochemical tests showed that total cholesterol and HDL cholesterol levels were statistically significantly decreased in the group treated with HML compared to the stress-induced group. Melatonin was measured in the blood, but there was no significant difference in the group treated with HML compared to the group with stress-induced group, but it tended to increase. IL-2 was measured in the blood, no significant change was observed in the group treated with HML compared to the stress-induced group.
Conclusions : According to the above results, HML maybe help with hematological changes expressed by caffeine and light-induced stress.
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KEYWORD
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Stress, Relaxation, Caffeine, Lycii Fructus
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